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HRID2195700

反应详情

EQUATION

反应方程式

HRID 2195700 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Cc1ccc(S(=O)(=O)ON)cc1
HCID10965249

Amino 4-methylbenzenesulfonate

C7H9NO3S

结构：N#Cc1c(N)nc2ccc(I)cc2c1O
HCID178510457

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc(S(=O)(=O)[O-])cc1.N#Cc1c(O)c2cc(I)ccc2[n+](N)c1N
HCID178427653

未命名化合物

收率 57.4%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

0.62 g 2-amino-3-cyano-4-hydroxy-6-iodoquinoline in 10 ml of dimethylformamide is stirred with 1 g of solid potassium carbonate for 40 minutes. Then, 0.6 g O-tosylhydroxylamine in 14 ml dichloromethane is added dropwise to the reaction mixture. Stirring at room temperature is continued for 4 hours. The precipitated crystalline material is filtered off and dried to obtain 0.57 g of the title compound (MH+: 327).

WORKUP

后处理

  1. filtrationThe precipitated crystalline material is filtered off
  2. customdried