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HRID2195987

反应详情

EQUATION

反应方程式

HRID 2195987 的结构方程式

REACTANTS

反应物

3
结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：CN1CCc2[nH]c3ccc(Cl)cc3c2C1
HCID19615

未命名化合物

结构：C=Cc1ccc(=O)n(C(F)(F)F)c1
HCID68756952

未命名化合物

PRODUCTS

生成物

1
结构：CN1CCc2c(c3cc(Cl)ccc3n2CCc2ccc(=O)n(C(F)(F)F)c2)C1
HCID57876012

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN1CCCC1=O
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

The title compound is prepared from a mixture of 8-chloro-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole, 1-(trifluoromethyl)-5-vinylpyridin-2(1H)-one and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

WORKUP

后处理

  1. customranging between 25 deg C
  2. customto 100 deg C
  3. customThe product obtained
  4. customis isolated by preparative HPLC