HRID2196076

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21866389

未命名化合物

结构：CN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)S(=O)(=O)c3ccccc3[N+](=O)[O-])ccc21

HCID68674244

未命名化合物

PRODUCTS

生成物

结构：CN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)S(=O)(=O)c3ccccc3[N+](=O)[O-])ccc21.Cl

HCID68674358

未命名化合物

收率 65%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A 4N-hydrogen chloride ethyl acetate solution (0.57 ml) was added to an ethyl acetate solution (1 ml) of 2-nitro-N-(2-pyridin-3-ylethyl)-N-[3-(1,3,3,5-tetramethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yloxy)propyl]benzenesulfonamide (236 mg), and stirred at room temperature for 1 minute. The precipitated insoluble matter was collected by filtration, washed with ethyl acetate, and dried to thereby obtain 163 mg (yield: 65%) of 2-nitro-N-(2-pyridin-3-ylethyl)-N-[3-(1,3,3,5-tetramethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yloxy)propyl]benzenesulfonamide hydrochloride as a white powder.

WORKUP

后处理

filtrationThe precipitated insoluble matter was collected by filtration
washwashed with ethyl acetate
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-72d656e3077b43a99710c5a9c40ef885
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08338406B2
来源说明: uspto-grants-2012_12

反应 SMILES

C(OC(=O)C)C.[ClH:7].[N+:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17]([N:20]([CH2:42][CH2:43][C:44]1[CH:45]=[N:46][CH:47]=[CH:48][CH:49]=1)[CH2:21][CH2:22][CH2:23][O:24][C:25]1[CH:41]=[CH:40][C:28]2[N:29]([CH3:39])[C:30](=[O:38])[C:31]([CH3:37])([CH3:36])[C:32](=[O:35])[N:33]([CH3:34])[C:27]=2[CH:26]=1)(=[O:19])=[O:18])([O-:10])=[O:9]>C(OCC)(=O)C>[ClH:7].[N+:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17]([N:20]([CH2:42][CH2:43][C:44]1[CH:45]=[N:46][CH:47]=[CH:48][CH:49]=1)[CH2:21][CH2:22][CH2:23][O:24][C:25]1[CH:41]=[CH:40][C:28]2[N:29]([CH3:39])[C:30](=[O:38])[C:31]([CH3:36])([CH3:37])[C:32](=[O:35])[N:33]([CH3:34])[C:27]=2[CH:26]=1)(=[O:18])=[O:19])([O-:10])=[O:9]