4-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine → 6-(4-Fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidin-2-amine

HRID 2196124Notes

Reaction equation

HRID 2196124 reaction equation
O1CCCOC1[CH2:7][CH2:8][C:9]1[C:10]2[N:19]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[CH:17]=[CH:16][C:11]=2[N:12]=[C:13]([NH2:15])[N:14]=1.Cl[C:28]1N=C(C(C)C)C2N=C(C3C=CC(F)=CC=3)C=CC=2N=1>>[F:26][C:23]1[CH:22]=[CH:21][C:20]([C:18]2[CH:17]=[CH:16][C:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:9]([CH:8]([CH3:7])[CH3:28])[C:10]=3[N:19]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 249638714-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamineHCID 579067492-Chloro-6-(4-fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidine

Product 1

HCID 249638696-(4-Fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidin-2-amine

Procedure

The procedure for the synthesis of 4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine was repeated, except for the use of 2-chloro-6-(4-fluoro-phenyl)-4-isopropyl-pyrido[3,2-d]pyrimidine instead of 2-chloro-4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidine. The resulting title compound was characterized as follows: MS (m/z) 283.0 [M+H]+; HPLC Rt=3.42 minutes (Method A).

Sources & evidence

ORD record
ord-1b46554620804c1faa7f915a45a4442a
Source dataset
uspto-grants-2012_12
Patent number
US08338435B2

Reaction notes

Loading…