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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2196124Generated: October 29, 2026

4-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine → 6-(4-Fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidin-2-amine

https://huagongshe.com/reaction/2196124

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamineHCID 24963871—
Reactant2-Chloro-6-(4-fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidineHCID 57906749—
Product6-(4-Fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidin-2-amineHCID 24963869—

Reaction Steps

The procedure for the synthesis of 4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine was repeated, except for the use of 2-chloro-6-(4-fluoro-phenyl)-4-isopropyl-pyrido[3,2-d]pyrimidine instead of 2-chloro-4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidine. The resulting title compound was characterized as follows: MS (m/z) 283.0 [M+H]+; HPLC Rt=3.42 minutes (Method A).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08338435B2
Source datasetuspto-grants-2012_12
ORD IDord-1b46554620804c1faa7f915a45a4442a
Source noteuspto-grants-2012_12