HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine → 6-(4-Fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine | HCID 24963871 | — |
| Reactant | 2-Chloro-6-(4-fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidine | HCID 57906749 | — |
| Product | 6-(4-Fluorophenyl)-4-isopropyl-pyrido[3,2-d]pyrimidin-2-amine | HCID 24963869 | — |
Reaction Steps
The procedure for the synthesis of 4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine was repeated, except for the use of 2-chloro-6-(4-fluoro-phenyl)-4-isopropyl-pyrido[3,2-d]pyrimidine instead of 2-chloro-4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidine. The resulting title compound was characterized as follows: MS (m/z) 283.0 [M+H]+; HPLC Rt=3.42 minutes (Method A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338435B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-1b46554620804c1faa7f915a45a4442a |
| Source note | uspto-grants-2012_12 |