4-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine → 4-Cyclopropyl-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-2-amine

HRID 2196125Notes

Reaction equation

HRID 2196125 reaction equation
O1CCCO[CH:2]1[CH2:7][CH2:8][C:9]1[C:10]2[N:19]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[CH:17]=[CH:16][C:11]=2[N:12]=[C:13]([NH2:15])[N:14]=1.ClC1N=C(C2CC2)C2N=C(C3C=CC(F)=CC=3)C=CC=2N=1>>[CH:8]1([C:9]2[C:10]3[N:19]=[C:18]([C:20]4[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=4)[CH:17]=[CH:16][C:11]=3[N:12]=[C:13]([NH2:15])[N:14]=2)[CH2:7][CH2:2]1

Participants

3

Reactant 2

HCID 249638714-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamineHCID 579067542-Chloro-4-cyclopropyl-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidine

Product 1

HCID 249635224-Cyclopropyl-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-2-amine

Procedure

The procedure for the synthesis of 4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine was repeated, except for the use of 2-chloro-4-cyclopropyl-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidine instead of 2-chloro-4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidine. The compound was characterized as follows: MS (m/z) 281.0 [M+H]+; HPLC Rt=2.96 minutes (Method A).

Sources & evidence

ORD record
ord-fbf925edea58415685984e90a096b8a9
Source dataset
uspto-grants-2012_12
Patent number
US08338435B2

Reaction notes

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