HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine → 4-Cyclopropyl-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-[1,3]Dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine | HCID 24963871 | — |
| Reactant | 2-Chloro-4-cyclopropyl-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidine | HCID 57906754 | — |
| Product | 4-Cyclopropyl-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-2-amine | HCID 24963522 | — |
Reaction Steps
The procedure for the synthesis of 4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine was repeated, except for the use of 2-chloro-4-cyclopropyl-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidine instead of 2-chloro-4-(2-[1,3]dioxan-2-yl-ethyl)-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidine. The compound was characterized as follows: MS (m/z) 281.0 [M+H]+; HPLC Rt=2.96 minutes (Method A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338435B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-fbf925edea58415685984e90a096b8a9 |
| Source note | uspto-grants-2012_12 |