N-(4,6-Dichloropyrido[3,2-d]pyrimidin-2-yl)acetamide → HCID 57906752, compound

HRID 2196126Notes

Reaction equation

HRID 2196126 reaction equation
Cl[C:2]1[C:3]2[N:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:4]=2[N:5]=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[N:7]=1.ClC1N=C(Cl)C2N=[C:26]([C:28]3[CH:33]=CC(F)=CC=3)C=CC=2N=1>>[Cl:16][C:14]1[CH:13]=[CH:12][C:4]2[N:5]=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[N:7]=[C:2]([CH:33]3[CH2:28][CH2:26]3)[C:3]=2[N:15]=1

Participants

3

Reactant 2

HCID 57698319N-(4,6-Dichloropyrido[3,2-d]pyrimidin-2-yl)acetamideHCID 596478432,4-Dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine

Product 1

HCID 57906752HCID 57906752, compound

Procedure

The experimental procedure of example 12 was repeated, except for the use of N-(4,6-dichloro-pyrido[3,2-d]pyrimidin-2-yl)-acetamide (a compound described in WO 2006/135993) instead of 2,4-dichloro-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidine. The resulting compound was characterized as follows: MS (m/z) 263.0 [M+H]+; HPLC Rt=2.24 minutes (Method B).

Sources & evidence

ORD record
ord-4729ee1b1e7946158edd495c1ff876a7
Source dataset
uspto-grants-2012_12
Patent number
US08338435B2

Reaction notes

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