反应详情

A solution of 4-bromo-1-fluoro-2-nitromethyl-benzene (7.75 g, 33.1 mmol), formaldehyde (35%, aqueous) (5.47 ml, 69.5 mmol) and Et3N (2.3 ml, 16.56 mmol) were stirred in 66 ml dioxane for 3 h. The solution was diluted with brine and extracted with TBME. The organic layer was washed with brine, dried with Na2SO4 and evaporated. The crude product was purified by chromatography on silica gel (heptane/EtOAc 3/1) to provide the title compound as a white solid.

1. extractionextracted with TBME
2. washThe organic layer was washed with brine
3. dry with materialdried with Na2SO4
4. customevaporated
5. customThe crude product was purified by chromatography on silica gel (heptane/EtOAc 3/1)