反应详情

温度

68 °C

A mixture of 5-difluoromethyl-5-(2-fluoro-phenyl)-morpholin-3-one (141 g, 575 mmol) and Lawesson's reagent (132 g, 316 mmol) in 1400 ml of THF was heated at 68° C. for 1 h, cooled down and then evaporated. The residue was dissolved in 1 L DCM and filtered over 2 Kg silica gel with 10 L DCM to give 161 g of the title compound in the form of a greenish resin that slowly crystallized. The compound was used without further purification.

1. temperaturecooled down
2. customevaporated
3. dissolutionThe residue was dissolved in 1 L DCM
4. filtrationfiltered over 2 Kg silica gel with 10 L DCM