HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one → 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one | HCID 68509193 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one | HCID 11278230 | — |
Reaction Steps
A mixture of 3-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one (0.333 g) and 48% HBr (30 mL) was heated at reflux for 8 h. The reaction was concentrated to give 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one as a brown solid, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338449B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-deda1e5048994e28a521e712c3f2e232 |
| Source note | uspto-grants-2012_12 |