3-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one → 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one

HRID 2196388Notes

Reaction equation

HRID 2196388 reaction equation
[C:1]([C:5]1[N:6]([CH3:24])[C:7](=[O:23])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11]([O:21]C)=[CH:10][CH:9]=2)([CH3:4])([CH3:3])[CH3:2]>Br>[C:1]([C:5]1[N:6]([CH3:24])[C:7](=[O:23])[C:8]2[C:13]([C:14]=1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[CH:12][C:11]([OH:21])=[CH:10][CH:9]=2)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 685091933-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one

Product 1

HCID 112782303-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A mixture of 3-tert-butyl-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one (0.333 g) and 48% HBr (30 mL) was heated at reflux for 8 h. The reaction was concentrated to give 3-tert-butyl-6-hydroxy-2-methyl-4-phenylisoquinolin-1(2H)-one as a brown solid, which was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 8 h
  3. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-deda1e5048994e28a521e712c3f2e232
Source dataset
uspto-grants-2012_12
Patent number
US08338449B2

Reaction notes

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