反应详情

KMnO4 (174 mg, 1.1 mmol) in H2O was added dropwise to a solution of (5-bromo-4-chloro-2-pyridinyl)methanol (187 mg, 0.846 mmol) in 10% Na2CO3 (1 mL). After 2 h, the solution was filtered through Celite®, adjusted to pH ˜4 and the resulting precipitate was filtered then azeotropically dried with toluene affording the title compound (135 mg, 68%) as a white powder: LCMS (ES) m/z=237 (M+H)+.

1. filtrationthe solution was filtered through Celite®
2. filtrationthe resulting precipitate was filtered
3. dry with materialthen azeotropically dried with toluene affording the title compound (135 mg, 68%) as a white powder