HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Permanganate → 5-Bromo-4-chloropyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Permanganate | HCID 516875 | — |
| Reactant | (5-Bromo-4-chloropyridin-2-yl)methanol | HCID 19791171 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Sodium Carbonate | HCID 10340 | — |
| Product | 5-Bromo-4-chloropyridine-2-carboxylic acid | HCID 58386654 | — |
Reaction Steps
KMnO4 (174 mg, 1.1 mmol) in H2O was added dropwise to a solution of (5-bromo-4-chloro-2-pyridinyl)methanol (187 mg, 0.846 mmol) in 10% Na2CO3 (1 mL). After 2 h, the solution was filtered through Celite®, adjusted to pH ˜4 and the resulting precipitate was filtered then azeotropically dried with toluene affording the title compound (135 mg, 68%) as a white powder: LCMS (ES) m/z=237 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338434B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-608892ddeed049afa11b1803466c8a98 |
| Source note | uspto-grants-2012_12 |