HCID 86642134, compound → HCID 25050807, compound

HRID 2196415Notes

Reaction equation

HRID 2196415 reaction equation
CC([N:5]([CH2:9][CH:10]([NH:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([C:27]2[N:31]([CH3:32])[N:30]=[CH:29][C:28]=2[Cl:33])=[C:23]([F:34])[CH:22]=1)=[O:20])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)C(=O)[O-])(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:5][CH2:9][CH:10]([NH:18][C:19](=[O:20])[C:21]1[CH:26]=[CH:25][C:24]([C:27]2[N:31]([CH3:32])[N:30]=[CH:29][C:28]=2[Cl:33])=[C:23]([F:34])[CH:22]=1)[CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 1

HCID 86642134HCID 86642134, compound

Product 1

HCID 25050807HCID 25050807, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of 1,1-dimethylethyl[2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate in TFA-DCM (3 mL, 1:2) was stirred at 25° C. After 30 min, the solution was concentrated and the residue neutralized through a silica plug (4% MeOH in DCM (1% NH4OH)) affording the free base of the title compound.

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-ab781e84a4704450baa0fd8586f03ab3
Source dataset
uspto-grants-2012_12
Patent number
US08338434B2

Reaction notes

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