HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86642134, compound → HCID 25050807, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86642134 | HCID 86642134 | — |
| Solvent | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | HCID 25050807 | HCID 25050807 | — |
Reaction Steps
A solution of 1,1-dimethylethyl[2-({[4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl]carbonyl}amino)-3-phenylpropyl]carbamate in TFA-DCM (3 mL, 1:2) was stirred at 25° C. After 30 min, the solution was concentrated and the residue neutralized through a silica plug (4% MeOH in DCM (1% NH4OH)) affording the free base of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338434B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-ab781e84a4704450baa0fd8586f03ab3 |
| Source note | uspto-grants-2012_12 |