Hydrazine hydrate (1:1) → HCID 59355011, compound

HRID 2196428Notes

Reaction equation

HRID 2196428 reaction equation
O.NN.O=C1C2C(=CC=CC=2)C(=O)[N:6]1[CH2:15][C@@H:16]([NH:28][C:29](=[O:42])[C:30]1[CH:35]=[CH:34][C:33]([C:36]2[N:40]([CH3:41])[N:39]=[CH:38][N:37]=2)=[CH:32][CH:31]=1)[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]([F:27])([F:26])[F:25]>C(Cl)Cl.CO>[NH2:6][CH2:15][C@@H:16]([NH:28][C:29](=[O:42])[C:30]1[CH:35]=[CH:34][C:33]([C:36]2[N:40]([CH3:41])[N:39]=[CH:38][N:37]=2)=[CH:32][CH:31]=1)[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]([F:27])([F:26])[F:25]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59354988HCID 59354988, compound

Product 1

HCID 59355011HCID 59355011, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Hydrazine hydrate (0.028 ml, 0.58 mmol) was added to a solution of N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1-methyl-1H-1,2,4-triazol-5-yl)benzamide (67.3 mg, 0.116 mmol) in DCM/MeOH (1/0.1 ml).

Sources & evidence

ORD record
ord-5b35585e0a914c9dbc9dc9177db0980a
Source dataset
uspto-grants-2012_12
Patent number
US08338434B2

Reaction notes

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