反应详情

温度

70 °C

A mixture of methyl 4-(1-methyl-1H-1,2,3-triazol-5-yl)benzoate (0.5 g, 2.30 mmol) and Sodium hydroxide (4.60 ml, 9.21 mmol, 2N aqueous solution) in tetrahydrofuran (THF) was heated at 70° C. for 1 hr. The organic layer was washed with H2O 3× and discarded. The combined aqueous layers were acidified with 2N HCl aqueous solution. The product precipitated and was filtered, rinsed with H2O and dried under vacuum to give 0.3 g (74%) as a tan solid. LC-MS (ES) m/z=204 (M+H)+.

1. washThe organic layer was washed with H2O 3×
2. customThe product precipitated
3. filtrationwas filtered
4. washrinsed with H2O
5. customdried under vacuum
6. customto give 0.3 g (74%) as a tan solid