反应详情

100 mg of 2-(benzofuran-3-yl)-6-bromoimidazo[1,2-a]pyridine, 73 mg of 3-(hydroxymethyl)phenylboronic acid and 11 mg of tetrakis(triphenylphosphine)palladium are placed in a microwave tube. 2 ml of acetonitrile, 2 ml of toluene and 1.5 ml of a 2M solution of sodium carbonate are added thereto. The tube is placed in a microwave device and irradiated at 150° C. for 15 min. The organic phase is separated, dried, and then concentrated under reduced pressure. The oily residue is taken up with 3 ml of dichloromethane and triturated for 1 hour. The precipitate is recovered by filtration, washed with diisopropyl ether and dried in a desiccator under reduced pressure. 44 mg of compound are obtained.

1. customirradiated at 150° C. for 15 min
2. customThe organic phase is separated
3. customdried
4. concentrationconcentrated under reduced pressure
5. customtriturated for 1 hour
6. filtrationThe precipitate is recovered by filtration
7. washwashed with diisopropyl ether
8. customdried in a desiccator under reduced pressure