Di-tert-butyl 1-(5-cyanothiophen-2-yl)hydrazine-1,2-dicarboxylate → HCID 69090430, compound

HRID 2196510Notes

Reaction equation

HRID 2196510 reaction equation
[ClH:1].N(C1C=C(C#N)SC=1)N.[C:11]([C:13]1[S:17][C:16]([N:18](C(OC(C)(C)C)=O)[NH:19]C(OC(C)(C)C)=O)=[CH:15][CH:14]=1)#[N:12]>>[Cl-:1].[C:11]([C:13]1[S:17][C:16]([NH2+:18][NH2:19])=[CH:15][CH:14]=1)#[N:12]

Participants

3

Reactant 2

HCID 59843233Di-tert-butyl 1-(5-cyanothiophen-2-yl)hydrazine-1,2-dicarboxylateHCID 69299496HCID 69299496, compound

Product 1

HCID 69090430HCID 69090430, compoundYield 78%

Procedure

Following the same procedure as described for compound 13 (step 3, scheme 2, example 1c) except using 20 (692 mg, 2.04 mmol) instead of 12 to afford 21 (278 mg, 78%) as a brown solid. LRMS (ESI): calc. 139.0; found 140.1 (MH)+.

Sources & evidence

ORD record
ord-38a1cb427a69415090af08e47c5bfba8
Source dataset
uspto-grants-2012_12
Patent number
US08338437B2

Reaction notes

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