Sodium Hydroxide → HCID 59843235, compound

HRID 2196547Notes

Reaction equation

HRID 2196547 reaction equation
C([O:3][C:4]([C:6]1[N:10]([CH:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]2)[N:9]=[C:8]([C:24]([F:27])([F:26])[F:25])[CH:7]=1)=[O:5])C.[OH-].[Na+]>C(O)C>[C:20]([O:19][C:17]([N:14]1[CH2:13][CH2:12][CH:11]([N:10]2[C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8]([C:24]([F:25])([F:26])[F:27])=[N:9]2)[CH2:16][CH2:15]1)=[O:18])([CH3:23])([CH3:21])[CH3:22]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 59843183HCID 59843183, compound

Product 1

HCID 59843235HCID 59843235, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred suspension of 93 (500 mg, 1.278 mmol) in ethanol (4.3 mL) was added a solution of NaOH (1.916 mL, 2N, 3.83 mmol) and the mixture was stirred at room temperature for 1 h, then it was concentrated and 1N HCl was added till the solution reached PH-1. Extraction with EtOAc and normal work-up gave crude 101 as colorless oil. LRMS (ESI): calc. 363.3; found 386.2 (MNa)+.

Workup

  1. concentrationit was concentrated
  2. addition1N HCl was added till the solution
  3. extractionExtraction with EtOAc and normal work-up

Sources & evidence

ORD record
ord-145f480bc55f45f88b44b2c001602ef4
Source dataset
uspto-grants-2012_12
Patent number
US08338437B2

Reaction notes

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