Sodium Carbonate → HCID 178488050, compound

HRID 2196549Notes

Reaction equation

HRID 2196549 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[NH:10][C:11]([C:13]1[N:17]([CH:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][N:26]([CH3:34])[C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30])[CH2:20][CH2:19]2)[N:16]=[C:15]([C:35]([F:38])([F:37])[F:36])[CH:14]=1)=O.C([O-])([O-])=O.[Na+].[Na+]>C(O)(=O)C>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]2[NH:1][C:11]([C:13]3[N:17]([CH:18]4[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][N:26]([CH3:34])[C:27](=[O:33])[O:28][C:29]([CH3:31])([CH3:30])[CH3:32])[CH2:20][CH2:19]4)[N:16]=[C:15]([C:35]([F:36])([F:38])[F:37])[CH:14]=3)=[N:10][C:3]=2[CH:4]=1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 59843143tert-butyl 2-(4-(5-(2-amino-5-methoxyphenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)piperidin-1-yl)ethyl(methyl)carbamate

Product 1

HCID 178488050HCID 178488050, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
90 °C

Procedure

Acetic acid (1.591 mL) was added to compound 106 (86 mg, 0.159 mmol) and the solution was allowed to stir for 2 h at 90° C. The reaction was cooled and neutralized with a solution of saturated Na2CO3 and extract with AcOEt. After the usual work-up crude 106 was obtained as a light yellow solid. LRMS (ESI): calc. 522.7; found 523.4 (MH)+.

Workup

  1. temperatureThe reaction was cooled
  2. extractionextract with AcOEt
  3. customAfter the usual work-up crude 106 was obtained as a light yellow solid

Sources & evidence

ORD record
ord-c9cdfd30a5cb454eb279028dc0e82640
Source dataset
uspto-grants-2012_12
Patent number
US08338437B2

Reaction notes

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