Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | tert-butyl 2-(4-(5-(2-amino-5-methoxyphenylcarbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)piperidin-1-yl)ethyl(methyl)carbamate | HCID 59843143 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 178488050 | HCID 178488050 | — |
Reaction Steps
Acetic acid (1.591 mL) was added to compound 106 (86 mg, 0.159 mmol) and the solution was allowed to stir for 2 h at 90° C. The reaction was cooled and neutralized with a solution of saturated Na2CO3 and extract with AcOEt. After the usual work-up crude 106 was obtained as a light yellow solid. LRMS (ESI): calc. 522.7; found 523.4 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08338437B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-c9cdfd30a5cb454eb279028dc0e82640 |
|---|
| Source note | uspto-grants-2012_12 |
|---|
