HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-n-(3-(1-(2-(methylamino)ethyl)piperidin-4-yl)phenyl)benzamide → 2-Methoxy-n-(2-nitro-4-(1,2,3,6-tetrahydropyridin-4-yl)phenyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-n-(3-(1-(2-(methylamino)ethyl)piperidin-4-yl)phenyl)benzamide | HCID 59843180 | — |
| Reactant | tert-butyl 4-(4-amino-3-nitrophenyl)-5,6-dihydropyridine-1(2H)-carboxylate | HCID 59843222 | — |
| Product | 2-Methoxy-n-(2-nitro-4-(1,2,3,6-tetrahydropyridin-4-yl)phenyl)benzamide | HCID 59843196 | 71% |
Reaction Steps
The title compound 202 (1.04 g, 2.22 mmol, 71%) was prepared following the procedures described for the synthesis of 192 (scheme 33, Example 36, steps 5 and 6) using 201 (1.00 g, 3.13 mmol) in place of 190. LRMS (ESI): calc. 353.1, found 411.3 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338437B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-494cc6c5c36b41ce9114254ebf87b5d7 |
| Source note | uspto-grants-2012_12 |