Trifluoroacetic acid → HCID 69298524, compound

HRID 2196579Notes

Reaction equation

HRID 2196579 reaction equation
C(O[C:6]([N:8](C)[CH2:9][CH2:10][N:11]([CH2:19][C:20]1[S:21][CH:22]=[C:23]([N:25]2[C:29]([C:30](=[O:41])[NH:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=3[O:39][CH3:40])=[CH:28][C:27]([C:42]([F:45])([F:44])[F:43])=[N:26]2)[CH:24]=1)C(=O)OC(C)(C)C)=O)(C)(C)C.C(O)(C(F)(F)F)=O.N[C@@H](C)C(NCC1SC=C(N2C(C(NCC3C=CC=CC=3OC)=O)=CC(C(F)(F)F)=N2)C=1)=O>>[CH3:40][O:39][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=1[CH2:32][NH:31][C:30]([C:29]1[N:25]([C:23]2[CH:24]=[C:20]([CH2:19][NH:11][CH2:10][CH2:9][NH:8][CH3:6])[S:21][CH:22]=2)[N:26]=[C:27]([C:42]([F:43])([F:44])[F:45])[CH:28]=1)=[O:41]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 25218467HCID 25218467, compoundHCID 69299483HCID 69299483, compound2×

Product 1

HCID 69298524HCID 69298524, compound

Procedure

The title compound 214 (133 mg, bis-TFA salt) was obtained as a white fluffy solid following the procedure described for the synthesis of 9a (scheme 2, example 1c, step 9) using 214 (135 mg, 0.202 mmol) in place of 15a

Sources & evidence

ORD record
ord-c0f3e9810ee14445a72da018f3465a4b
Source dataset
uspto-grants-2012_12
Patent number
US08338437B2

Reaction notes

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