反应详情

Hydrogen chloride gas is bubbled into a solution of 3-({[2-(3-fluoro-phenyl)-pyrimidine-5-carbonyl]-amino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester (3.76 mmol) in DCM (20 mL) and the reaction is stirred at room temperature for 2 hours. The mixture is concentrated in vacuo to afford 2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid (piperidin-3-ylmethyl)-amide hydrochloride as a solid. MS 415 (M+H); 1H NMR (300 MHz, CD3OD): δ 1.22-1.50 (m, 2H), 1.68-1.90 (m, H), 1.90-2.06 (bs, 2H), 2.06-2.17 (bs, 6H), 2.73-3.04 (m, 2H), 3.24-3.50 (m, H), 7.24-7.35 (m, H), 7.48-7.60 (m, H), 8.19 (d, H), 8.34 (d, H), 9.23 (s, 2H).

1. concentrationThe mixture is concentrated in vacuo