HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2196801Generated: October 26, 2026
Triethylamine → 2-Fluoro-5-(methylsulfonylmethyl)pyridine
https://huagongshe.com/reaction/2196801
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (6-Fluoropyridin-3-yl)methanol | HCID 22663702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Fluoro-5-(methylsulfonylmethyl)pyridine | HCID 66660787 | — |
Reaction Steps
(6-Fluoropyridin-3-yl)methanol (215 mg, 1.69 mmol) in CH2Cl2 (10 mL) containing triethylamine (354 μL, 2.54 mmol) was treated with methanesulfonyl chloride (291 mg, 2.54 mmol) dropwise at 0° C., stirred at 0° C. for 30 min, diluted with water, and extracted with CH2Cl2 (2×10 mL). The combined organic extract was dried (MgSO4), filtered, and concentrated to afford a crude oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08338467B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-1061e110aae94e449ce405f420a9894e |
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| Source note | uspto-grants-2012_12 |
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