反应详情

温度

0 °C

(6-Fluoropyridin-3-yl)methanol (215 mg, 1.69 mmol) in CH2Cl2 (10 mL) containing triethylamine (354 μL, 2.54 mmol) was treated with methanesulfonyl chloride (291 mg, 2.54 mmol) dropwise at 0° C., stirred at 0° C. for 30 min, diluted with water, and extracted with CH2Cl2 (2×10 mL). The combined organic extract was dried (MgSO4), filtered, and concentrated to afford a crude oil.

1. extractionextracted with CH2Cl2 (2×10 mL)
2. extractionThe combined organic extract
3. dry with materialwas dried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated
6. customto afford a crude oil