Trifluoroacetic acid → HCID 86623470, compound

HRID 2196853Notes

Reaction equation

HRID 2196853 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[C:9]([N:11]1[CH2:15][CH2:14][C:13](=[N:16][O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:12]1[CH3:25])=[O:10])(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:18]([O:17][N:16]=[CH:13][CH:12]1[CH2:25][CH2:14][CH2:15][N:11]1[C:9](=[O:10])[C@@H:8]([NH2:7])[CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86623471{(S)-2-[benzyloxylimino-methyl-pyrrolidine-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

Product 1

HCID 86623470HCID 86623470, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The solution of {(S)-2-[benzyloxylimino-methyl-pyrrolidine-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester (1.76 g, 3.97 mmole) and TFA (10 ml) in dichloromethane (20 ml) is stirred for a hour. Solvent is removed under vacuum. The residue is carried to next step without further purification. M+H+=344.2

Workup

  1. customSolvent is removed under vacuum
  2. customThe residue is carried to next step without further purification

Sources & evidence

ORD record
ord-ef5398a60c63495b9326d74a7592285a
Source dataset
uspto-grants-2012_12
Patent number
US08338440B2

Reaction notes

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