反应详情

24.8 g of piperazine (287.9 mmol) were dissolved in 350 ml of ethanol and heated to reflux. 24.9 g of 2-tert-butyl-4-chloro-6-cyclobutyl-pyrimidine (48.06 mmol), dissolved in 50 ml of ethanol, were added dropwise to the solution. The solution was refluxed for further 3 h, cooled to room temperature and then extracted with water and ethyl acetate. The organic layer was washed with 5% citric acid (aq.), and the aqueous layer was adjusted to alkaline pH with 2 N NaOH. The alkaline aqueous layer was reextracted with ethyl acetate, and the organic phase was dried over magnesium sulfate, filtered and concentrated to dryness to yield 8.6 g (65.2%) of the title compound.

1. temperatureheated to reflux
2. additionwere added dropwise to the solution
3. temperatureThe solution was refluxed for further 3 h
4. extractionextracted with water and ethyl acetate
5. washThe organic layer was washed with 5% citric acid (aq.)
6. dry with materialthe organic phase was dried over magnesium sulfate
7. filtrationfiltered
8. concentrationconcentrated to dryness