反应详情

温度

50 °C

25.1 g of piperazine (291.4 mmol) were dissolved in 100 ml of ethanol and heated to 50° C. 17 g of 2-tert-butyl-4-chloro-6-cyclopropyl-pyrimidine (81 mmol), dissolved in 100 ml of ethanol, were added dropwise within 2 h. After heating to reflux at 70° C. for 5 h the reaction mixture was stirred at room temperature overnight. The ethanol was evaporated and the residue suspended in 200 ml of water. The aqueous phase was extracted 4 times with 100 ml of dichloromethane each. Drying over magnesium sulfate, filtration, and evaporation to dryness gave 19.2 g (90.9%) of the title compound.

1. additionwere added dropwise within 2 h
2. temperatureAfter heating
3. temperatureto reflux at 70° C. for 5 h the reaction mixture
4. customThe ethanol was evaporated
5. extractionThe aqueous phase was extracted 4 times with 100 ml of dichloromethane each
6. dry with materialDrying over magnesium sulfate, filtration, and evaporation to dryness