HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → {4-[4-(2-tert-Butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]-butyl}-methyl-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | {4-[4-(2-tert-Butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]-butyl}methyl-carbamic acid tert-butyl ester | HCID 69028122 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | {4-[4-(2-tert-Butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]-butyl}-methyl-amine hydrochloride | HCID 69028787 | — |
Reaction Steps
0.5 g of {4-[4-(2-tert-butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]-butyl}-methyl-carbamic acid tert-butyl ester (1.06 mmol) were treated with 10 ml of a 4 N solution of hydrochloric acid in dioxane for 16 h. The solvent was evaporated to yield 0.6 g of the deprotected amine as its hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202868B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-05a02836953c465ea5826183e3242c50 |
| Source note | uspto-grants-2012_06 |