Hydrochloric Acid → {4-[4-(2-tert-Butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]-butyl}-methyl-amine hydrochloride

HRID 219702Notes

Reaction equation

HRID 219702 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16]([C:19]2[CH:24]=[C:23]([CH:25]3[CH2:28][CH2:27][CH2:26]3)[N:22]=[C:21]([C:29]([CH3:32])([CH3:31])[CH3:30])[N:20]=2)[CH2:15][CH2:14]1)C)(C)(C)C.[ClH:34]>O1CCOCC1>[ClH:34].[C:29]([C:21]1[N:20]=[C:19]([N:16]2[CH2:15][CH2:14][N:13]([CH2:12][CH2:11][CH2:10][CH2:9][NH:7][CH3:6])[CH2:18][CH2:17]2)[CH:24]=[C:23]([CH:25]2[CH2:28][CH2:27][CH2:26]2)[N:22]=1)([CH3:32])([CH3:30])[CH3:31]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69028122{4-[4-(2-tert-Butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]-butyl}methyl-carbamic acid tert-butyl ester

Product 1

HCID 69028787{4-[4-(2-tert-Butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]-butyl}-methyl-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.5 g of {4-[4-(2-tert-butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]-butyl}-methyl-carbamic acid tert-butyl ester (1.06 mmol) were treated with 10 ml of a 4 N solution of hydrochloric acid in dioxane for 16 h. The solvent was evaporated to yield 0.6 g of the deprotected amine as its hydrochloride salt.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-05a02836953c465ea5826183e3242c50
Source dataset
uspto-grants-2012_06
Patent number
US08202868B2

Reaction notes

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