Hydrochloric Acid → HCID 69029345, compound

Participants

Reaction Steps

1.5 g of 5-[4-(2-tert-butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]-pentanenitrile (4.22 mmol) were dissolved in 40 ml of dichloromethane and 0.4 g of dry ethanol (8.7 mmol). Gaseous hydrochloric acid was introduced into the solution until saturation at 0° C. The reaction was stirred for 15 h at room temperature and concentrated to dryness. The resulting crude product (2.18 g) was directly used in the next reaction step.

Provenance & Evidence