Hydrochloric Acid → HCID 69029345, compound

HRID 219713Notes

Reaction equation

HRID 219713 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][C:21]#[N:22])[CH2:13][CH2:12]2)[CH:8]=[C:7]([CH:23]2[CH2:26][CH2:25][CH2:24]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:27]([OH:29])[CH3:28].[ClH:30]>ClCCl>[ClH:30].[CH2:27]([O:29][C:21](=[NH:22])[CH2:20][CH2:19][CH2:18][CH2:17][N:14]1[CH2:13][CH2:12][N:11]([C:9]2[CH:8]=[C:7]([CH:23]3[CH2:26][CH2:25][CH2:24]3)[N:6]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[N:10]=2)[CH2:16][CH2:15]1)[CH3:28]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 69027750HCID 69027750, compound

Product 1

HCID 69029345HCID 69029345, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.5 g of 5-[4-(2-tert-butyl-6-cyclobutyl-pyrimidin-4-yl)-piperazin-1-yl]-pentanenitrile (4.22 mmol) were dissolved in 40 ml of dichloromethane and 0.4 g of dry ethanol (8.7 mmol). Gaseous hydrochloric acid was introduced into the solution until saturation at 0° C. The reaction was stirred for 15 h at room temperature and concentrated to dryness. The resulting crude product (2.18 g) was directly used in the next reaction step.

Workup

  1. concentrationconcentrated to dryness
  2. customThe resulting crude product (2.18 g) was directly used in the next reaction step

Sources & evidence

ORD record
ord-1bf28b646610440194a1f1b30be5db98
Source dataset
uspto-grants-2012_06
Patent number
US08202868B2

Reaction notes

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