2-tert-Butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-cyclobutyl-pyrimidine → 2-tert-Butyl-4-cyclobutyl-6-{4-[3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanyl)-propyl]-piperazin-1-yl}-pyrimidine hydrochloride

HRID 219717Notes

Reaction equation

HRID 219717 reaction equation
[CH3:1][C:2]1[S:6][C:5]([SH:7])=[N:4][N:3]=1.[C:8]([C:12]1[N:17]=[C:16]([N:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][Cl:27])[CH2:20][CH2:19]2)[CH:15]=[C:14]([CH:28]2[CH2:31][CH2:30][CH2:29]2)[N:13]=1)([CH3:11])([CH3:10])[CH3:9]>>[ClH:27].[C:8]([C:12]1[N:13]=[C:14]([CH:28]2[CH2:29][CH2:30][CH2:31]2)[CH:15]=[C:16]([N:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][S:7][C:5]3[S:6][C:2]([CH3:1])=[N:3][N:4]=3)[CH2:20][CH2:19]2)[N:17]=1)([CH3:11])([CH3:9])[CH3:10]

Participants

3

Reactant 2

HCID 666731042-tert-Butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-cyclobutyl-pyrimidineHCID 178434161HCID 178434161, compound

Product 1

HCID 690269532-tert-Butyl-4-cyclobutyl-6-{4-[3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanyl)-propyl]-piperazin-1-yl}-pyrimidine hydrochloride

Procedure

Using the method of example 1, the title compound was prepared by reacting of 5-methyl-[1,3,4]thiadiazol-2-thiol with 2-tert-butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-cyclobutyl-pyrimidine and converting the isolated compound into its hydrochloride salt.

Sources & evidence

ORD record
ord-3b3da900b0c047d78513f35c389006fc
Source dataset
uspto-grants-2012_06
Patent number
US08202868B2

Reaction notes

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