HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-tert-Butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-cyclobutyl-pyrimidine → 2-tert-Butyl-4-cyclobutyl-6-{4-[3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanyl)-propyl]-piperazin-1-yl}-pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-tert-Butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-cyclobutyl-pyrimidine | HCID 66673104 | — |
| Reactant | HCID 178434161 | HCID 178434161 | — |
| Product | 2-tert-Butyl-4-cyclobutyl-6-{4-[3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanyl)-propyl]-piperazin-1-yl}-pyrimidine hydrochloride | HCID 69026953 | — |
Reaction Steps
Using the method of example 1, the title compound was prepared by reacting of 5-methyl-[1,3,4]thiadiazol-2-thiol with 2-tert-butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-cyclobutyl-pyrimidine and converting the isolated compound into its hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202868B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-3b3da900b0c047d78513f35c389006fc |
| Source note | uspto-grants-2012_06 |