反应详情

温度

80 °C

A mixture of the compound obtained in step g above (22g) (759 mg, 1.907 mmol) and 3 N HCl (20 mL) was stirred at 80° C. for 2 h. The reaction mixture was cooled down and then extracted with EtOAc. The combined organic layers were dried and concentrated; the crude product was purified by silica gel column chromatography which gave the title compound as colorless oil (300 mg, 41%).

1. temperatureThe reaction mixture was cooled down
2. extractionextracted with EtOAc
3. customThe combined organic layers were dried
4. concentrationconcentrated
5. customthe crude product was purified by silica gel column chromatography which