Hydrochloric Acid → HCID 86654171, compound

Participants

Reaction Conditions

Reaction Steps

11 g of the tert-butyl ester of 4-(3-thiophen-2-yl[1,2,4]-oxadiazol-5-yl)piperidine-1-carboxylic acid (32.8 mmol) were placed in a 250 ml round-bottomed flask and dissolved in 66 ml of absolute ethanol. A solution of hydrogen chloride in dioxane (4N) (10 ml) was then added. The reaction medium was heated at 50° C. for 2 hours. The solution was then cooled and 100 ml of diethyl ether were added. The product was then filtered off. 9.56 g of a beige-colored powder were obtained.

Provenance & Evidence