Hydrochloric Acid → HCID 86654171, compound

HRID 2197439Notes

Reaction equation

HRID 2197439 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:10]=[C:9]([CH:11]2[CH2:16][CH2:15][N:14](C(O)=O)[CH2:13][CH2:12]2)[O:8][N:7]=1.[ClH:20].C(OCC)C>C(O)C.O1CCOCC1>[ClH:20].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:10]=[C:9]([CH:11]2[CH2:16][CH2:15][NH2+:14][CH2:13][CH2:12]2)[O:8][N:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 67252056HCID 67252056, compound

Product 1

HCID 86654171HCID 86654171, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

11 g of the tert-butyl ester of 4-(3-thiophen-2-yl[1,2,4]-oxadiazol-5-yl)piperidine-1-carboxylic acid (32.8 mmol) were placed in a 250 ml round-bottomed flask and dissolved in 66 ml of absolute ethanol. A solution of hydrogen chloride in dioxane (4N) (10 ml) was then added. The reaction medium was heated at 50° C. for 2 hours. The solution was then cooled and 100 ml of diethyl ether were added. The product was then filtered off. 9.56 g of a beige-colored powder were obtained.

Workup

  1. temperatureThe solution was then cooled
  2. filtrationThe product was then filtered off

Sources & evidence

ORD record
ord-bad33efb24fa4f0bba953a3175d17905
Source dataset
uspto-grants-2012_12
Patent number
US08338599B2

Reaction notes

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