Phenyl isocyanate → HCID 24804918, compound

HRID 2197444Notes

Reaction equation

HRID 2197444 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[S:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[C:16]1[N:20]=[C:19]([CH:21]2[CH2:26][CH2:25][NH2+:24][CH2:23][CH2:22]2)[O:18][N:17]=1>N1C=CC=CC=1>[C:1]1([NH:7][C:8]([N:24]2[CH2:25][CH2:26][CH:21]([C:19]3[O:18][N:17]=[C:16]([C:12]4[S:11][CH:15]=[CH:14][CH:13]=4)[N:20]=3)[CH2:22][CH2:23]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 86654171HCID 86654171, compound

Product 1

HCID 24804918HCID 24804918, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

40 μl (1 eq.) of phenyl isocyanate were added to a solution of 100 mg (1 eq.) of 4-(3-thiophen-2-yl[1,2,4]oxadiazol-5-yl)piperidinium hydrochloride in 0.6 ml of pyridine. The reaction medium was stirred at room temperature overnight and then evaporated under reduced pressure. The residue obtained was chromatograph on a thick layer of silica (eluent: CH2Cl2/MeOH (95/5; v/v)). After evaporating off the solvent, 48 mg (37%) of the expected compound were obtained.

Workup

  1. customevaporated under reduced pressure
  2. customThe residue obtained
  3. customAfter evaporating off the solvent

Sources & evidence

ORD record
ord-e3b6d0ab6227462f921fada85174b565
Source dataset
uspto-grants-2012_12
Patent number
US08338599B2

Reaction notes

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