Phenyl isocyanate → HCID 24804918, compound

Participants

Reaction Steps

40 μl (1 eq.) of phenyl isocyanate were added to a solution of 100 mg (1 eq.) of 4-(3-thiophen-2-yl[1,2,4]oxadiazol-5-yl)piperidinium hydrochloride in 0.6 ml of pyridine. The reaction medium was stirred at room temperature overnight and then evaporated under reduced pressure. The residue obtained was chromatograph on a thick layer of silica (eluent: CH2Cl2/MeOH (95/5; v/v)). After evaporating off the solvent, 48 mg (37%) of the expected compound were obtained.

Provenance & Evidence