反应详情

温度

110 °C

8.9 ml of ethylpiperazine are placed in 91.5 ml of toluene in a round-bottomed flask. A solution of 4.1 ml of ethyl bromoacetate in 11.6 ml of toluene is added dropwise. The mixture is refluxed at 110° C. for one hour, concentrated to a small volume and left in a refrigerator for 3 hours. A white precipitate forms, which is filtered off and washed with dichloromethane. The filtration liquors are evaporated; 7 g of expected product are obtained.

1. concentrationconcentrated to a small volume
2. filtrationA white precipitate forms, which is filtered off
3. washwashed with dichloromethane
4. filtrationThe filtration liquors
5. customare evaporated