Ethyl bromoacetate → Ethyl 4-ethyl-1-piperazineacetate

HRID 219760Notes

Reaction equation

HRID 219760 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:2].Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]>C1(C)C=CC=CC=1>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:5][CH2:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 791961-Ethylpiperazine

Product 1

HCID 22199027Ethyl 4-ethyl-1-piperazineacetate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Conditions

Temperature
110 °C

Procedure

8.9 ml of ethylpiperazine are placed in 91.5 ml of toluene in a round-bottomed flask. A solution of 4.1 ml of ethyl bromoacetate in 11.6 ml of toluene is added dropwise. The mixture is refluxed at 110° C. for one hour, concentrated to a small volume and left in a refrigerator for 3 hours. A white precipitate forms, which is filtered off and washed with dichloromethane. The filtration liquors are evaporated; 7 g of expected product are obtained.

Workup

  1. concentrationconcentrated to a small volume
  2. filtrationA white precipitate forms, which is filtered off
  3. washwashed with dichloromethane
  4. filtrationThe filtration liquors
  5. customare evaporated

Sources & evidence

ORD record
ord-9b4229f69e0541a18224b8eb7beed869
Source dataset
uspto-grants-2012_06
Patent number
US08202871B2

Reaction notes

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