Chloroacetic Acid → HCID 85554416, compound

HRID 2197607Notes

Reaction equation

HRID 2197607 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][CH:6]=1.[Cl:7][CH2:8][C:9]([OH:11])=[O:10].C(O)C>CC(C)=O>[Cl-:7].[C:9]([CH2:8][N+:3]1[C:2]([CH3:1])=[CH:6][S:5][CH:4]=1)([OH:11])=[O:10]

Participants

5

Reactant 3

HCID 300Chloroacetic AcidHCID 702EthanolHCID 127484-Methylthiazole

Product 1

HCID 85554416HCID 85554416, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

15.6 g of 4-methylthiazole was dissolved in 50 ml of anhydrous acetone. The mixture was added with 15 g of chloroacetic acid, stirred for 5 d, filtered to obtain a solid, and a white solid was then obtained by recrystallization from ethanol, dired to obtain 20.4 g product with a yield of 66.9%, mP=262.3-263.6° C.

Workup

  1. filtrationfiltered
  2. customto obtain a solid

Sources & evidence

ORD record
ord-ec6cdb7536624e52882715ed53aa76a1
Source dataset
uspto-grants-2012_12
Patent number
US08338616B2

Reaction notes

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