HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetic acid → (1-Ethyl-1,2,3,6-tetrahydropyrid-4-yl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | 1-Ethylpiperidin-4-one | HCID 77159 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (1-Ethyl-1,2,3,6-tetrahydropyrid-4-yl)acetonitrile | HCID 66602178 | 122.6% |
Reaction Steps
2.9 g of 1-ethyl-4-piperidone, 3.3 g of cyanoacetic acid and 36 ml of toluene are placed in a round-bottomed flask equipped with a magnetic stirrer, and under a stream of nitrogen. The mixture is refluxed for 4 hours, while removing the water using Markusson apparatus. The solvent is evaporated off under vacuum. 4.2 g of oil are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202871B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-9a34e0d9277f498ebb1ff39c1fbc7ffc |
| Source note | uspto-grants-2012_06 |