Phosphorus oxychloride → 5-Chloro-2-propyl-[1,8]naphthyridine

HRID 2197701Notes

Reaction equation

HRID 2197701 reaction equation
[CH2:1]([C:4]1[N:13]=[C:12]2[C:7]([C:8](O)=[CH:9][CH:10]=[N:11]2)=[CH:6][CH:5]=1)[CH2:2][CH3:3].O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:8]1[CH:9]=[CH:10][N:11]=[C:12]2[C:7]=1[CH:6]=[CH:5][C:4]([CH2:1][CH2:2][CH3:3])=[N:13]2

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178438802HCID 178438802, compound

Product 1

HCID 441401765-Chloro-2-propyl-[1,8]naphthyridineYield 86%

Procedure

The product from Example 2f (145 mg, 0.76 mmol) was reacted with POCl3 4 mL following the procedure from Example 1d giving the title compound as a solid (135 mg, 86%).

Sources & evidence

ORD record
ord-00a36bb699f24c29bfa4a5cd9b981433
Source dataset
uspto-grants-2012_12
Patent number
US08338605B2

Reaction notes

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