Diethyl 2-((6-ethylpyridin-2-ylamino)methylene)malonate → Ethyl 7-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

HRID 2197706Notes

Reaction equation

HRID 2197706 reaction equation
C(O[C:4](=[O:21])[C:5](=[CH:11][NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][CH3:20])[N:14]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])C>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH2:9]([O:8][C:6]([C:5]1[C:4](=[O:21])[C:18]2[C:13](=[N:14][C:15]([CH2:19][CH3:20])=[CH:16][CH:17]=2)[NH:12][CH:11]=1)=[O:7])[CH3:10]

Participants

3

Reactant 1

HCID 12354398Diethyl 2-((6-ethylpyridin-2-ylamino)methylene)malonate

Product 1

HCID 12354420Ethyl 7-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylateYield 80%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

The product of Example 3c (7.16 g, 0.024 mol) was heated in diphenyl ether following the procedure in Example 1b giving the title compound (4.73 g, 79%) as a tan solid.

Sources & evidence

ORD record
ord-63a01db66aac44a184252bc2a723237d
Source dataset
uspto-grants-2012_12
Patent number
US08338605B2

Reaction notes

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