Phosphorus oxychloride → 5-Chloro-2-ethyl-1,8-naphthyridine

HRID 2197708Notes

Reaction equation

[CH2:1]([C:3]1[N:12]=[C:11]2[C:6]([C:7](O)=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1)[CH3:2].O=P(Cl)(Cl)[Cl:16]>>[Cl:16][C:7]1[CH:8]=[CH:9][N:10]=[C:11]2[C:6]=1[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[N:12]2

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178435554HCID 178435554, compound

Product 1

HCID 672512035-Chloro-2-ethyl-1,8-naphthyridineYield 83%

Procedure

The product from Example 3e (200 mg, 1.14 mmol) was treated with POCl3 following the procedure from Example 1d giving the title compound as a brown solid (183 mg, 83%).

Sources & evidence

ORD record: ord-5654f8be5c934c9f95e7e47822862eb3
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08338605B2

Reaction notes

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