HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 3-(4-Chloro-2-nitro-phenoxy)-N,N-dimethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 3-(4-Chloro-2-nitro-phenoxy)-benzoyl chloride | HCID 86615500 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(4-Chloro-2-nitro-phenoxy)-N,N-dimethyl-benzamide | HCID 68458301 | 92.6% |
Reaction Steps
To the product from Example 168b (2.0 g, 6.4 mmol) in THF (25 mL) was added dimethylamine (0.6 g, 13.3 mmol) and the reaction stirred for 16 h. The reaction was poured into water and extracted with ethyl acetate. The organic layer washed with 5% HCL, water, brine, and dried over sodium sulfate, filtered and concentrated under vacuum giving the title compound (1.9 g, 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338605B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-14b8e40f0be04bcb8d31812498fa0610 |
| Source note | uspto-grants-2012_12 |