反应详情

To the product from Example 168b (2.0 g, 6.4 mmol) in THF (25 mL) was added dimethylamine (0.6 g, 13.3 mmol) and the reaction stirred for 16 h. The reaction was poured into water and extracted with ethyl acetate. The organic layer washed with 5% HCL, water, brine, and dried over sodium sulfate, filtered and concentrated under vacuum giving the title compound (1.9 g, 87%).

1. extractionextracted with ethyl acetate
2. washThe organic layer washed with 5% HCL, water, brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated under vacuum